Innovent - Eli Lilly's Sintilimab Combo Shows Sustained Survival Benefit In Lung Cancer Patients

  • Innovent Biologics Inc IVBIY and Eli Lilly And Co LLY have announced new and updated data from the ORIENT-11 Phase 3 study of sintilimab as first-line treatment of nonsquamous non-small cell lung cancer (NSCLC).
  • The trial assessed sintilimab in combination with pemetrexed and platinum chemotherapy.
  • The findings were published in the Journal of Thoracic Oncology. 
  • As of January 15, 2021, with a median follow-up of 22.9 months, the median overall survival (OS) of patients receiving the sintilimab combination was not yet reached. 
  • The sintilimab combination demonstrated a sustainable OS benefit, and the median OS for those receiving the placebo combination was 16.8 months.
  • Biomarker analysis showed that high or medium immune cell infiltration was strongly associated with improved progression-free survival (PFS) in the sintilimab combination group. 
  • In particular, high MHC class-II presentation pathway expression was significantly correlated with prolonged PFS and OS in the sintilimab combination group.
  • Price Action: LLY shares are down 0.53% at $262.85 on the last check Friday.
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Posted In: BiotechNewsHealth CareGeneralBriefsNon-Small Cell Lung Cancer
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