Novartis Shares Two Year Beovu Data From Diabetic Macular Edema Studies

  • Novartis AG NVS has reported data from two Phase 3 trials assessing Beovu (brolucizumab) 6 mg versus Regeneron Pharmaceuticals Inc's REGN Eylea (aflibercept) 2 mg in patients with diabetic macular edema (DME).
  • Two-year (week 100) data of the KITE study showed consistent results as one year of greater reductions versus aflibercept in central subfield thickness (CSFT), a number of eyes with retinal fluid (a biomarker of the disease), and maintenance of best-corrected visual acuity (BCVA).
  • Year two findings from KESTREL, another pivotal Phase 3 trial of Beovu in DME, are due to read out in Q4 of 2021.
  • Another Phase 3 trial, KINGFISHER, met its primary endpoint of non-inferiority to aflibercept in the change in BCVA from baseline at year one (week 52) when dosed every four weeks. 
  • Further details of KITE and KINGFISHER will be presented at upcoming medical meetings.
  • Related: Novartis Terminates Three Beovu Studies in Ocular Disorders Citing Patient Safety.
  • Price Action: NVS shares closed 0.67% higher at $94.46 on Monday.
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Posted In: BiotechNewsHealth CareGeneralBriefsDiabetic Macular Edema
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