Biggest Losers (SPPI, ACOR, LEAP, LXRX, CLRT)

Spectrum Pharmaceuticals, Inc. (NASDAQ: SPPI) fell 16.75% to $5.17 on huge volume of 7.73 million shares after it said U.S. health regulators have not approve its supplementary marketing application for its advanced metastatic colorectal cancer drug Fusilev in its current form.

Acorda Therapeutics Inc. (NASDAQ: ACOR) plummeted 17.37% to $18.41 on unusual volume of 5.60 million shares after the company announced that the U.S. Food and Drug Administration (FDA) has posted on its website briefing documents for the Peripheral and Central Nervous System Drugs Advisory Committee meeting to review Acorda's New Drug Application (NDA) for Fampridine-SR for the proposed indication of improvement of walking ability in people with multiple sclerosis (MS).

Leap Wireless International, Inc. (NASDAQ: LEAP) decreased $0.87 or 5.04% to $16.39 on 3.24 million shares on no news. The stock is trading very close to its 52-week low of $14.18.

Lexicon Pharmaceuticals, Inc. (NASDAQ: LXRX) is the among the top percentage losers and now fell 12.99% to $1.54 on very unusual volume of 3.90 million shares s it announced the pricing of a public offering of 33,333,333 shares of its common stock at $1.50 per share, of which 19,894,076 shares are being offered through the underwriters and 13,439,257 shares are being offered to Invus, L.P., Lexicon Pharmaceuticals, Inc.'s stockholder.

Clarient, Inc. (NASDAQ: CLRT) plunged 8.27% to $3.87 on very unusual volume of 847K shares on no news. In the last six months shares of RINO have rallied over 56%.