Investors Cheer Onconova's Rigosertib Combo Data In Lung Cancer Setting

  • Onconova Therapeutics Inc ONTX has announced preliminary data from Phase 1/2a trial of rigosertib plus Bristol-Myers Squibb Co's BMY Opdivo (nivolumab) in advanced KRAS mutated non-small cell lung cancer (NSCLC). 
  • The trial included patients who failed two or more lines of prior therapy, and all have failed immune checkpoint inhibitors in various combinations.
  • Data showed that 2 of 7 (29%) evaluable patients achieved a partial response (PR), and 3 of 7 (43%) evaluable patients achieved disease control.
  • 4 of 7 (57%) evaluable patients experienced progressive disease.
  • The combination of rigosertib and nivolumab has been well-tolerated, and the maximum tolerated dose has not been reached to date. 
  • Treatment-related adverse events were primarily mild with two severe adverse events.
  • Three patients discontinued study drug (two moderate genitourinary toxicities, one dose-limiting severe hyponatremia)
  • No unexpected safety events or synergistic toxicities have been observed.
  • Onconova will host a webinar today at 4:30 p.m. ET to discuss the preliminary Phase 1/2a data.
  • Price Action: ONTX shares are up 25.5% at $6.15 during the market session on the last check Wednesday.
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