Mirati Posts More Responses For Adagrasib-Keytruda Combo In Lung Cancer Setting

In its Q3 earnings release, Mirati Therapeutics Inc MRTX posted preliminary results from the Phase 1b cohort of the KRYSTAL-1 study evaluating adagrasib plus Merck & Co Inc’s MRK Keytruda (pembrolizumab) in KRAS-mutated first-line non-small cell lung cancer (NSCLC).
The Company said that a combination of adagrasib and Keytruda posted four partial responses among eight previously untreated patients.
In the KRYSTAL-1 study, the adagrasib-Keytruda combo posted a 100% disease control rate, with all seven evaluable patients showing tumor regression ranging from 37% to 92%.
The safety results from the update were slim, but Mirati did highlight that there were no Grade 4 side effects or deaths reported.
Mirati posted License and collaboration revenues of $71.8 million, with a narrower than expected EPS loss of $(1.55) compared to a consensus of $(2.89).
The Company ended Q3 with cash, cash equivalents, and short-term investments of $1.2 billion.
Related Link: Mirati Posts Adagrasib Data In KRAS-Mutated Lung Cancer, FDA Filing Now On The Cards.
Price Action: MRTX shares gained 8.80% and closed at $$173.98 during Monday after-hours session.

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