Genmab, BioNTech Join Forces For Cancer Immunotherapy Candidates

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  • Genmab A/S GMAB and BioNTech SE BNTX have expanded their global strategic collaboration to develop and commercialize novel cancer immunotherapies.
  • Under the expansion, Genmab and BioNTech will jointly work to research, develop, and commercialize novel monospecific antibody candidates for various cancer indications. 
  • The expanded collaboration will leverage Genmab's HexaBody technology platform. 
  • The first monospecific antibody candidate, GEN1053/BNT313, is expected to enter clinical trials by the end of 2022.
  • The companies will equally share the development costs and potential future profit from GEN1053/BNT313.
  • Since 2015, the companies have been working on the joint development of bispecific cancer antibodies.
  • The companies currently have two jointly developed investigational medicines in clinical testing since 2019, including:
    • GEN1046/BNT311 in phase 1/2 trials for advanced solid tumors and a phase 2 study for non-small cell lung cancer.
    • GEN1042/BNT312 in Phase 1/2 study for metastatic or locally advanced solid tumors.
  • Price Action: GMAB stock is down 2.72% at $35.03 on the last check Friday.
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