SELLAS Life Sciences Touts Encouraging Preclinical Data For Candidate For Aggressive Form Of Prostate Cancer

  • SELLAS Life Sciences Group Inc SLS announced results from a new preclinical in vitro study for its highly selective CDK9 inhibitor, GFH009, in neuroendocrine prostate cancer (NEPC). 
  • The data shows that GFH009 demonstrated significant anti-tumor effects in the selected cell line at nanomolar concentrations and, in certain samples, complete growth inhibition with no viable cancer cells.
  • Also See: SELLAS Life Sciences's Galinpepimut/Opdivo Combo Shows Increased Survival In Mesothelioma Patients.
  • NEPC is an aggressive variant of prostate cancer. In up to 15%-20% of patients treated with hormonal therapies for prostate adenocarcinoma, small-cell prostate cancer may develop in later stages of prostate cancer progression. 
  • Median survival for NEPC patients whose cancer arose from prior prostate adenocarcinoma is estimated at only 5.4 months. 
  • The conversion to NEPC is associated with recurrent genetic lesions, including mutation or deletion of RB1 and TP53 and the overexpression and genomic amplification of MYCN. 
  • Price Action: SLS shares are up 0.83% at $3.35 on the last check Wednesday.
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