Astria Therapeutics' Potential Hereditary Angioedema Candidate Shows Encouraging Action In Healthy Participants

  • Astria Therapeutics Inc ATXS announced preliminary results from the Phase 1a trial of STAR-0215 in healthy subjects.
  • The company says that data establishes early proof of concept of STAR-0215 as a potential long-acting preventative treatment for hereditary angioedema (HAE). 
  • STAR-0215 was well-tolerated at all doses studied. 
  • The results showed rapid and sustained drug levels consistent with clinical benefit and sustained target engagement with plasma kallikrein inhibition for at least three months, supporting the potential for STAR-0215 to be dosed once every three months or less frequently. 
  • Astria plans to initiate the ALPHA-STAR Phase 1b/2 trial in HAE patients in Q1 2023.
  • Initial results are expected from the single and multiple dose cohorts in mid-2024.
  • Astria plans to evaluate the potential for 6-month dosing with additional healthy subject cohorts in the Phase 1a trial starting in Q1 2023, with initial results expected in Q4 2023.
  • Concurrently, Astria priced an underwritten offering of 9.08 million shares at $11.01 per share for gross proceeds of $100 million.
  • Price Action: ATXS shares are up 2.18% at $11.25 during the premarket session on the last check Thursday.
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