Why Aclaris Therapeutics Stock Is Plunging Today

  • Aclaris Therapeutics Inc ACRS announced preliminary topline results from a 12-week, Phase 2a study of zunsemetinib (ATI-450) for moderate to severe hidradenitis suppurativa.
  • The study did not meet its primary endpoint of change from baseline in inflammatory nodule/abscess count (AN) of zunsemetinib 50mg BID versus placebo at week 12. 
  • The study also did not meet the secondary efficacy endpoints assessed in the topline data, including the percentage of patients achieving HiSCR-50. 
  • The placebo effect observed across all efficacy endpoints was higher than observed in other published HS studies reported to date.
  • Zunsemetinib was generally well tolerated. Safety findings were generally consistent with observations from prior clinical studies of zunsemetinib. 
  • PK and PD were generally consistent with observations from prior clinical studies of zunsemetinib. 
  • A preliminary analysis of endogenous plasma cytokines and chemokines in patients with a confirmed dose of study treatment on the day of blood draw demonstrated zunsemetinib-dependent inhibition relative to placebo. 
  • Price Action: ACRS shares are down 49.60% at $6.44 on the last check Monday.
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