Why Aclaris Therapeutics (ACRS) Stock Is Plunging Today - Aclaris Therapeutics (NASDAQ:ACRS)

Aclaris Therapeutics Inc ACRS announced preliminary topline results from a 12-week, Phase 2a study of zunsemetinib (ATI-450) for moderate to severe hidradenitis suppurativa.
The study did not meet its primary endpoint of change from baseline in inflammatory nodule/abscess count (AN) of zunsemetinib 50mg BID versus placebo at week 12.
The study also did not meet the secondary efficacy endpoints assessed in the topline data, including the percentage of patients achieving HiSCR-50.
The placebo effect observed across all efficacy endpoints was higher than observed in other published HS studies reported to date.
Zunsemetinib was generally well tolerated. Safety findings were generally consistent with observations from prior clinical studies of zunsemetinib.
PK and PD were generally consistent with observations from prior clinical studies of zunsemetinib.
A preliminary analysis of endogenous plasma cytokines and chemokines in patients with a confirmed dose of study treatment on the day of blood draw demonstrated zunsemetinib-dependent inhibition relative to placebo.
Price Action: ACRS shares are down 49.60% at $6.44 on the last check Monday.

Why Aclaris Therapeutics Stock Is Plunging Today