MindMed Reveals Topline Data From Mid-Stage Depression Study Evaluating Lysergide

  • Mind Medicine Inc's MNMD collaborators have released topline data from a double-blind, investigator-initiated trial evaluating lysergide major depressive disorder (MDD).
  • The topline data demonstrated significant, rapid, durable, and beneficial effects of lysergide and its potential to mitigate symptoms of MDD. 
  • The high-dose lysergide regimen in which patients received 100 µg on their first treatment day and 200 µg on a second treatment day (separated by four weeks) resulted in statistically and clinically significant improvements on the primary endpoint, a change in clinician-rated Inventory of Depressive Symptomatology (IDS-C) scores six weeks after the first administration as compared to control.
  • IDC-C scores measure behavioral manifestations and severity of depression.
  • Related: MindMed Reports Full-Year 2022 Financial Results, Highlighting Anxiety & Autism Studies.
  • The control group in this study received a lower dose regimen of 25 µg on both treatment days. 
  • Patients in the high dose arm (n=28) demonstrated a least square mean change from baseline in IDS-C scores of -12.9 points compared to -3.6 points in the lower dose arm (n=27, p=0.02). 
  • The statistically significant benefit measured by IDS-C was maintained up to 16 weeks after the first administration compared to the placebo (p=0.008). 
  • Secondary endpoints were also encouraging. 
  • The investigational drug was generally well tolerated.
  • The company said that improvements observed in this study reinforce preliminary findings that have shown the clinical potential of lysergide in anxiety, depression, and other brain health disorders.
  • Price Action: MNMD shares closed at $3.10 on Thursday.
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