UCSF Clinical Trial Shows Promising Results For Naturally-Sourced Psilocybin And Psilocin

A Phase 1 clinical trial led by the University of California San Francisco (UCSF) assessing research partner Filament Health Corp.’s FLHLF botanical psychedelic drug candidates has shown positive interim outcomes.

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The UCSF’s Translational Psychedelic Research Program (TrPR) administered a total of fifteen doses of the company’s naturally-sourced psilocybin (PEX010) as well as naturally-sourced psilocin (PEX020 and PEX030,) to four healthy subjects, reporting good tolerability and no serious or unexpected adverse events.

Filament is a clinical-stage natural psychedelic drug development company aiming to standardize naturally-derived psychedelic medicines.

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The company has stated that this is the first FDA-approved clinical trial of a naturally-derived psychedelic drug candidate and the first time psilocin has been directly administered in a clinical trial.

TrPR director and study PI Dr. Joshua Woolley added that “these are the first reported clinical trial results regarding a naturally sourced psychedelic drug.” He added that considering the drug candidates have been well-tolerated, the study will continue as planned.

Filament CEO and co-founder Benjamin Lightburn says the company is proud to continue its relationship with UCSF and “to have such promising early results.” 

“This industry-first trial is a testament to Filament’s innovative drug development and operational capabilities,” Lightburn concluded.

Photo: Benzinga edit with photo by Sisacorn and Bizi88 on Shutterstock.