Benzinga's Top #PreMarket Losers

Orexigen Therapeutics OREX dipped 12.63% to $5.95 in pre-market trading after the company received three month extension of the FDA NB32 review. Exelon EXC dropped 2.50% to $36.23 in pre-market trading after the company announced an offering of 50 million shares. Central European Media Enterprises CETV shares fell 1.75% to $2.80 in pre-market trading after gaining 0.71% on Tuesday. The Boeing Company BA shares dropped 1.16% to $135.66 in pre-market trading after RBC Capital downgraded the stock from Outperform to Sector Perform.