Benzinga's Top #PreMarket Losers

Tetraphase Pharmaceuticals Inc TTPH shares fell 79.57 percent to $9.15 in pre-market trading after failing to meet the primary endpoint of statistical non-inferiority for IGNITE2, compared to levofloxacin. Flexion Therapeutics Inc FLXN fell 27.93 percent to $20.90 in pre-market trading after failing to demonstrate statistical significance for the primary endpoint for FX006. Aquinox Pharmaceuticals Inc AQXP shares declined 12.29 percent to $13.77 in pre-market trading after the company reported a proposed public offering of $75 million of common stock. MannKind Corporation MNKD shares tumbled 8.85 percent to $3.71 in pre-market trading. Piper Jaffray downgraded MannKind from Neutral to Underweight and lowered the price target from $4 to $1.50. Yahoo! Inc. YHOO shares dipped 2.10 percent to $30.25 in pre-market trading after dropping 2.15 percent on Tuesday.