Eli Lilly Inks Another RNA Collab, This Time With ProQR

  • Eli Lilly And Co LLY is doubling down on RNA research as it pens another pact with a quiet RNA editing player focused on neuroscience, ProQR Therapeutics N.V. PRQR.
  • In May, Lilly teamed up with MiNA Therapeutics to tap its small activating RNA (saRNA) technology platform for up to five targets.
  • Related: Lilly, MiNA Ink Broad RNA Deal Worth $1.25B.
  • ProQR will receive an upfront payment of $20 million and an equity investment of $30 million, with up to $1.25 billion as milestone payments for five targets using its RNA platform.
  • ProQR’s oligonucleotide platform, dubbed Axiomer, recruits “endogenous” enzymes in the cell, called ADARs, to attach to target RNA and induce adenosine to inosine base switch.
  • This approach can potentially reverse more than 20,000 G to A mutations known to cause human disease.
  • Price Action: PRQR stock is up 13.36% at $7.72 during the premarket session on the last check Thursday, while LLY stock closed at $254.84 on Wednesday.
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