Benzinga's Top #PreMarket Losers

AcelRx Pharmaceuticals, Inc. ACRX shares fell 46.11% to $4.71 in pre-market trading. AcelRx received an FDA update regarding the NDA application for Zalviso. BlackBerry Limited BBRY shares declined 3.94% to $10.25 in pre-market trading. Goldman Sachs downgraded BlackBerry to Sell and lowered the price target from $10.00 to $9.00. Orexigen Therapeutics, Inc. OREX shares dropped 2.82% to $6.90 in pre-market after falling 11.36% on Friday. Michael Kors Holdings LimitedKORS fell 2.23% to $64.51 in pre-market trading after dropping 1.73% on Friday. McDonald's Corp. MCD shares dropped 1.16% to $96.00 in pre-market trading after the company reported a 1.7% drop in its global comparable sales in February.