PepGen (NASDAQ:PEPG) Stock

PepGen

PepGen Inc is a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapeutics to transform the treatment of severe neuromuscular and neurologic diseases. The company has developed its Enhanced Delivery Oligonucleotide platform to improve the uptake and activity of conjugated oligonucleotide therapeutics. Its EDO peptides are engineered to optimize tissue penetration, cellular uptake, and nuclear delivery, and in preclinical studies, it is observed their ability to transport oligonucleotides into a broad range of target tissues, including smooth, skeletal, and cardiac muscle and the central nervous system. Its pipeline products are; PGN-EDO51, PGN-EDODM1, and others including PGN-EDO53 and PGN-EDO45.

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PEPG

PepGen shares are trading higher by 90% during Monday&#39;s session. The company announced early data from its FREEDOM-DM1 trial for myotonic dystrophy.

Why PepGen (PEPG) Stock Is Skyrocketing Today

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Capricor Therapeutics Inc. (NASDAQ: CAPR) is a biotechnology firm focused on developing cell and exosome-based treatments for rare diseases like Duchenne muscular dystrophy (DMD).

Capricor Therapeutics Is Up Over 100%, Could Rise Even Higher

PepGen Inc

Gold prices hit an all-time high Monday as President Donald Trump's <a href="https://www.benzinga.com/news/global/25/02/43926015/trump-confirms-tariffs-on-canada-mexico-will-take-effect-as-planned">tariff threat</a> sent risk-on markets lower, driving demand for the safe haven asset.
What happened: Spot gold rose to $2,956 per ounce early morning before dipping to $2,937.67 as of this writing. Gold futures on the Commodity Exchange also climbed to an intraday high of 2,970.39 before settling at $2.952.
The yellow metal has gained 12.3% year-to-date and roughly 44% over the last 12 months.&nbsp;
Gold's rise contrasted with that of Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>), often dubbed the "digital gold" by its advocates, as the apex cryptocurrency slid 4.48% in the last 24 hours. Blue-chip stock indexes like the Nasdaq Composite and the S&amp;P 500 also closed <a href="https://www.benzinga.com/trading-ideas/movers/25/02/43930754/bitcoin-ethereum-dogecoin-bleed-amid-trumps-tariff-threat-bybit-mega-breach-analyst-says-mid-bull-reset-not-unprecedented-full-blown-bear-market-not-yet-here">Monday's trading session in the red</a>.
Meanwhile, Pax Gold (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/paxg/usd">PAXG</a>), a cryptocurrency backed by physical gold, was among the market&#8217;s biggest gainers in the last 24 hours.
See Also:<a href="https://www.benzinga.com/24/12/42735744/pharma-bro-martin-shkreli-predicts-doom-for-michael-saylors-microstrategy-as-stock-dips-below-300-in-after-hours-trading"> </a><a href="https://www.benzinga.com/general/entertainment/25/02/43905274/kanye-west-deletes-x-posts-on-potential-meme-coin-unfollows-changpeng-zhao-whats-he-upto">Kanye West Deletes X Posts On Potential Meme Coin, Unfollows Changpeng Zhao — What&#8217;s He Upto?</a>
Why It Matters: Peter Schiff, a renowned gold bug and Bitcoin critic, highlighted how SPDR Gold Trust ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GLD#NYSE">GLD</a>), the world's largest gold exchange-traded fund, has risen 12.42% year-to-date, while Bitcoin-tied ETFs have struggled.&nbsp;
"Instead of 2025 beginning a golden age for Bitcoin, it looks like it will just be a golden age," Schiff threw a jibe.
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Gold closed at yet another record high today, above $2,954. <a href="https://twitter.com/search?q=%24GLD&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$GLD</a> also closed at a record high, up 11% YTD. In contrast, ETFs that invest in fool&#39;s gold, aka Bitcoin, are down 3.5% YTD. Instead of 2025 beginning a golden age for Bitcoin, it looks like it will just be a golden age.
&mdash; Peter Schiff (@PeterSchiff) <a href="https://twitter.com/PeterSchiff/status/1894144793535463434?ref_src=twsrc%5Etfw">February 24, 2025</a></blockquote>
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While Bitcoin has certainly struggled this year, it has surpassed gold in terms of annual returns, rising more than 76% vs. the bullion metal's 44% returns.
On a larger time frame, the gulf becomes wider. Bitcoin has gained a whopping 35,807% in the last 10 years, compared to 142% return on gold investment. 
Price Action: At the time of writing, Bitcoin was exchanging hands at $$90,562.19, down 4.48% in the last 24 hours, according to <a href="https://pro.benzinga.com/dashboard?_gl=1&#x2A;380nj0&#x2A;_ga&#x2A;MTEyOTAyOTcxMy4xNzEzMzY0NTYy&#x2A;_ga_V7ZK73W7N0&#x2A;MTcxNDk4MzIzMi42LjEuMTcxNDk4OTE0Ni4wLjAuMA..">data from Benzinga Pro</a>. Year-to-date, it has lost 3.03% of its value.
Image Via Shutterstock
Read Next:
<ul>
<li><a href="https://www.benzinga.com/personal-finance/financial-advisors/25/02/43903229/advisors-remain-divided-on-crypto-but-sec-approvals-demand-are-shifting-views">Advisors Remain Divided On Crypto, But SEC Approvals, Demand Are Shifting Views</a></li>
</ul>

Coverage of Bitcoin, Etherum, Ripple and all the latest digital currencies.

Cryptocurrency

$BTC

$PAXG

Bitcoin Is Struggling In 2025 As Gold Clocks New All-Time High But Here Is The Full Picture

Deepwater Management&#8216;s Gene Munster&nbsp;has shared his insights on Apple&#8217;s recent announcement of $500 billion U.S. investments.
What Happened: On Tuesday, Munster took to X to present his analysis of&nbsp;Apple Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>)&#8217;s decision to ramp up its annual U.S. expenditures. He believes the tech giant is set to increase its annual U.S. investments by $39 billion, a 45% increase from the 2021 run rate. However, Munster suggests the actual&nbsp;incremental investment is closer to&nbsp;$20 billion annually.
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Three takeaways from $AAPL's announcement of investments in the US: 1- The quick math suggests Apple is increasing its annual US expenditures by $39B, up 45% from the run rate outlined in 2021. In reality, the incremental investment is closer to $20B annually. Prior to today's…
&mdash; Gene Munster (@munster_gene) <a href="https://twitter.com/munster_gene/status/1894086801452646772?ref_src=twsrc%5Etfw">February 24, 2025</a></blockquote>
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He also indicated that Apple&#8217;s announcement underscores its realization that an AI-powered future necessitates significant infrastructure investments. He estimates that 15% of the $19 billion incremental spend will be allocated to the hiring of 20,000 new employees, adding roughly $3 billion in annual employee expenses. The remaining 85% is likely to be invested in infrastructure, including expanding data center capacity and chip production for Apple Watches and iPads.
Munster&#8217;s third point underscores Apple&#8217;s strategic approach to bypass tariffs by redirecting those savings into U.S. investments. He estimates that the U.S. accounts for about 35% of Apple&#8217;s total sales, translating to approximately $147 billion in revenue this year. Of that, around $120 billion comes from product sales, which could be affected by the 10% tariffs. Hence, by boosting its domestic investments, Apple could potentially save at least $11 billion per year by avoiding the tariff. Put simply, tariff avoidance covers half of the additional $19 billion in U.S. investment announced.
SEE ALSO: <a href="https://www.benzinga.com/news/global/25/02/43926015/trump-confirms-tariffs-on-canada-mexico-will-take-effect-as-planned">Trump Confirms Tariffs On Canada, Mexico Will Take Effect As Planned</a>
Why It Matters: Apple CEO Tim Cook&#8216;s announcement of this massive investment in the U.S. is being widely perceived as a means to avoid the tariff threat. Tariffs have been a cause of major cause of concern for Apple. Bank of America analyst Analyst Wamsi Mohan had previously stated that iPhone manufacturers will need to increase prices on iPhones, iPads, and other <a href="https://www.benzinga.com/markets/equities/25/02/43839627/apple-may-hike-iphone-prices-by-9-due-to-trumps-tariffs-says-bank-of-america">products by about 9%</a> to offset the impact of tariffs.
Meanwhile, President <a href="https://www.benzinga.com/markets/25/02/43911774/trump-says-apples-500-billion-investment-is-due-to-his-policies-without-which-they-wouldnt-be-investing-ten-cents">Donald Trump stated</a> that the investment was a result of Apple&#8217;s confidence in his administration and policies. 
Apart from Gene Munster, several other analysts have presented their reactions to the iPhone maker&#8217;s $500 billion investment. UBS analyst David Vogt stated that  &#8220;it lacks substance&#8221;, while renowned short-seller James Chanos called it &#8220;unrealistic&#8221; considering Apple&#8217;s current capital base is less than $160 billion. On the other hand, Wedbush&#8217;s Dan Ives said, &#8220;Apple made the smart strategic move with this $500 billion bet on its US buildout.&#8221;
Apple stock closed 0.66% higher at $247.17 on Monday. 
<ul>
<li>READ MORE: <a href="https://www.benzinga.com/25/02/43932533/tesla-starts-rolling-out-fsd-features-in-china">Tesla Starts Rolling Out FSD Features In China A Month After Elon Musk Said EV Giant Faces &#8216;Challenges&#8217; In The Country</a></li>
</ul>
Image via Shutterstock
Disclaimer:&nbsp;This content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.

Equities

Short Sellers

Tech

AAPL

Apple Could Save $11 Billion Annually By Avoiding Tariffs As Tim Cook's Tech Giant Pledges $500 Billion US Investment, Says Top Analyst

Combining 5G Connectivity, Advanced Thermal Imaging, a Slim Design, and Built-to-Endure Toughness

SONM

Sonim XP Pro Thermal 5G Debuts With Military-Grade Durability And Real-Time Thermal Data Streaming

Skanska Selects DXC Technology To Overhaul IT Infrastructure, Boost Efficiency, And Strengthen Security

Teledyne e2v Introduces Lince5M NIR, A High-Speed 5.2MP Sensor For Advanced Industrial And Medical Imaging

"Our Bengaluru expansion represents a critical step in our continued commitment to scaling our global operations and enhancing support for customers worldwide," said Therese Tucker, Founder and co-CEO at BlackLine. "India's deep talent pool and thriving technology ecosystem make it an ideal location to drive innovation, expand our capabilities, and accelerate our global impact to meet growing customer demand."

BlackLine Expands Bengaluru Operations With A 50,000-Square-Foot Office To Drive Global Innovation And Growth

<ul>
<li>New agreement spans packet core, signaling, charging &amp; policy solutions</li>
</ul>

ERIC

Bharti Airtel Partners With Ericsson To Deploy Advanced 5G Core Technology For India's 5G Evolution

51Talk Integrates AI Across Its Platform, Enhancing Personalized Learning And Operational Efficiency

JPMorgan Chase (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/JPM#NYSE">JPM</a>) CEO Jamie Dimon has voiced criticism over the efficiency of the U.S. government and shown support for the Department of Government Efficiency (DOGE) overseen by Elon Musk.
What Happened: In an interview with <a href="https://www.cnbc.com/2025/02/24/jamie-dimon-us-government-inefficient-touts-elon-musk-doge-effort.html">CNBC</a>&#8216;s Leslie Picker on Monday, Dimon labeled the government as &#8220;inefficient&#8221; and &#8220;not very competent,&#8221; implying that it &#8220;needs a lot of work.&#8221; Although he didn&#8217;t provide a clear-cut response about his stance on DOGE&#8217;s initiatives, his remarks suggested a general endorsement.
Dimon also mentioned the Trump administration&#8217;s initiatives to cut spending and closely examine federal agencies, stating such actions &#8220;need to be done.&#8221; He underscored the need for building appropriate policies and procedures and questioned the benefits derived from government spending.
While Dimon expressed support for DOGE&#8217;s cost-cutting initiatives, he also cautioned against any potential overreach or illegal activities, stating that &#8220;the courts will stop it.&#8221; Nevertheless, Dimon added, "I'm hoping it's quite successful.&#8221;
SEE ALSO: <a href="https://www.benzinga.com/trading-ideas/movers/25/02/43930754/bitcoin-ethereum-dogecoin-bleed-amid-trumps-tariff-threat-bybit-mega-breach-analyst-says-mid-bull-reset-not-unprecedented-full-blown-bear-market-not-yet-here">Bitcoin, Ethereum, Dogecoin Bleed Amid Trump&#8217;s Tariff Threat, Bybit Mega Breach: Analyst Says &#8216;Mid-Bull Reset&#8217; Not Unprecedented, Full-Blown Bear Market Not Yet Here</a>
Why It Matters: Dimon&#8217;s comments come in the backdrop of his recent reconciliation with Elon Musk, CEO of Tesla Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>). In late January, Dimon referred to <a href="https://www.benzinga.com/startups/25/01/43339032/jamie-dimon-calls-elon-musk-our-einstein-after-years-of-feuds-weve-hugged-it-out-and-settled-differences-at-tech-summit">Musk as &#8216;Our Einstein&#8217;</a> after years of public feuds and legal disputes. The two reportedly &#8220;hugged it out&#8221; and settled their differences at a tech summit.
The JPMorgan CEO has also expressed his support for President Donald Trump&#8216;s tariff policy, previously. In January, he had told CNBC, that the upcoming tariffs by the Trump administration could be seen in a positive light. "If it's a little inflationary but it's good for national security, so be it. I mean, get over it," Dimon had said. 
Jamie Dimon recently courted controversy after he <a href="https://www.benzinga.com/markets/equities/25/02/43757032/jamie-dimon-goes-off-on-return-to-office-critics-you-dont-have-to-work-at-jpmorgan">condemned remote work</a>, arguing that it hinders creativity and negatively impacts the social and professional development of younger employees. 
Notably, while the JPMorgan CEO has voiced his support for Musk&#8217;s DOGE initiative, several others have criticized the transparency and working of DOGE. A <a href="https://www.benzinga.com/markets/25/02/43906977/elon-musks-doge-savings-of-55-billion-may-be-overstated-wsj-analysis-reveals-the-likely-actual-figure">recent analysis by WSJ</a> also revealed that the savings mentioned on the DOGE website could be overstated. 
<ul>
<li>READ MORE: <a href="https://www.benzinga.com/personal-finance/25/02/43929806/dave-ramsey-says-its-very-difficult-to-trust-someone-in-pajamas-on-a-zoom-call-admits-hes-the-crotchety-old-boss">Dave Ramsey Says &#8216;It&#8217;s Very Difficult To Trust Someone In Pajamas On A Zoom Call&#8217;—Admits He&#8217;s &#8216;The Crotchety Old Boss&#8217;</a></li>
</ul>
Image via Shutterstock
Disclaimer:&nbsp;This content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.

TSLA

Jamie Dimon Slams 'Inefficient' US Government, Backs Elon Musk's DOGE Initiative

EpoVIVE&#x2122;, an epoxy product portfolio offering a range of sustainable characteristics across multiple products, which will support customer sustainability initiatives. The EpoVIVE&#x2122; portfolio of Epoxy phenolic, resins and curing agents, represents a significant step forward in the commitment to drive sustainable innovation and foster value-chain collaboration. EpoVIVE&#x2122; products are developed with an environmentally conscious mindset.

Westlake Epoxy Introduces EpoVIVE At JEC World 2025, Advancing Sustainable Epoxy Solutions

<ul>
<li>Contentserv provides the all-in-one cloud-based platform for PIM, DAM, Content Syndication and Digital Shelf Analytics (DSA)</li>
<li>Platform enables FMCG companies to craft and optimize product content to reduce time to market, increase product sell-through and curate personalized consumer experiences</li>
</ul>

DASTY

Dassault Systemes' Centric Software Acquires AI-Powered PXM Leader Contentserv For €220M

Macro Economic Events

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Economics

Germany Gross Domestic Product (YoY) For Q4 -0.2% Vs. -0.2% Est.; -0.3% Prior

Germany Gross Domestic Product (QoQ) For Q4 -0.2% Vs. -0.2% Est.; 0.1% Prior

Sarclisa approved in Japan for patients with newly diagnosed multiple myeloma&nbsp;
<ul>
<li>Approval offers access to new treatment options for newly diagnosed MM patients</li>
<li>Approval based on positive results from the IMROZ phase 3 study that demonstrated Sarclisa in combination with VRd significantly improved progression-free survival, compared to VRd alone in transplant-ineligible newly diagnosed multiple myeloma</li>
</ul>

Sanofi Gains Japanese Approval For Sarclisa In Newly Diagnosed Multiple Myeloma Patients

Billionaire entrepreneur and Dallas Mavericks owner Mark Cuban has called the U.S. healthcare system, &#8220;f&#x2A;&#x2A;&#x2A;&#x2A;d up&#8221; while highlighting deductibles as &#8220;the biggest problem in healthcare,&#8221; which are designed by insurance companies.
What Happened: Cuban explained in his latest X post that insurance companies design plans with higher deductibles and lower premiums leaving the work of bill collection in the hands of doctors and hospitals.
A deductible is the amount of money paid by the patient before their insurance company pays for the covered expenses as chosen under their policy.
&#8220;Often we choose higher deductibles because we are healthy or because we can only afford the lowest premium plan,&#8221; adds Cuban, inferring that if higher deductibles were left unpaid hospitals end up becoming &#8220;bill collectors,&#8221; &#8220;DESPITE HAVING NO SAY in the (insurance) plans&#8221; and deductibles bracket that patients choose.
"That is one fucked up system that needs to be redesigned," adds Cuban.
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Want to know one of the biggest problems in healthcare? Deductibles. Deductibles are defined by the plans the insurance companies design. Then they are approved to be offered by the feds or employers. Then we the people decide what deductible we want when we choose our plans.…
&mdash; Mark Cuban (@mcuban) <a href="https://twitter.com/mcuban/status/1894236347847618571?ref_src=twsrc%5Etfw">February 25, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
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See Also: <a href="https://www.benzinga.com/government/regulations/25/02/43912631/apple-forced-to-kiss-the-ring-expert-questions-whether-trump-pushed-the-iphone-maker-for-500-billion-investment">Apple &#8216;Forced To Kiss The Ring&#8217;? Expert Questions Whether Trump Pushed The iPhone Maker For $500 Billion Investment</a>
Why It Matters: Cuban&#8217;s tweets shed light on the growing problem of high deductibles in the U.S. healthcare system.
The "higher deductibles" turn out to be out-of-pocket costs which create a barrier to accessing care, potentially leading to delayed treatment, worsening health conditions, and mounting medical debt.
Cuban concluded his post by calling out insurance company practices that contribute to healthcare costs, including &#8220;delay tactics&#8221; and denials of claims. He called for a redesigned system for patient well-being and fairness for healthcare providers.
Here is a list of Insurance sector ETFs that investors could look at:
<figure class="wp-block-table is-style-stripes"> 
<table>
<tbody>
<tr>
<td>ETFs</td>
<td>YTD Performance</td>
<td>One Year Performance</td>
</tr>
<tr>
<td>SPDR S&amp;P Insurance ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/KIE#NYSE">KIE</a>)</td>
<td>3.30%</td>
<td>17.59%</td>
</tr>
<tr>
<td>iShares US Insurance ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/IAK#NYSE">IAK</a>)</td>
<td>3.66%</td>
<td>17.32%</td>
</tr>
<tr>
<td>Invesco KBW Property &amp; Casualty Insurance ETF (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/KBWP#NASDAQ">KBWP</a>)</td>
<td>-0.33%</td>
<td>12.48%</td>
</tr>
</tbody>
</table>
</figure>
Price Action: The SPDR S&amp;P 500 ETF Trust (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SPY#NYSE">SPY</a>) and Invesco QQQ Trust ETF (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QQQ#NASDAQ">QQQ</a>), which track the S&amp;P 500 index and Nasdaq 100 index, respectively, fell on Monday. SPY declined 0.46% to $597.21, and QQQ plunged 1.18% to $519.87, according to <a href="https://pro.benzinga.com/dashboard">Benzinga Pro</a> data
Read Next:
<ul>
<li><a href="https://www.benzinga.com/25/02/43906366/warren-buffetts-berkshire-boosts-bets-on-five-japanese-companies-admiration-has-consistently-grown-says-oracle-of-omaha-in-letter-to-shareholders">Warren Buffett&#8217;s Berkshire Boosts Bets On 5 Japanese Companies: Oracle Of Omaha Says Admiration &#8216;Has Consistently Grown&#8217;</a></li>
</ul>
Photo courtesy: Shutterstock

Sector ETFs

Insurance

ETFs

iShares Dow Jones US Insurance Index Fund

KBWP

Mark Cuban Calls Deductibles 'The Biggest Problem' in Healthcare: 'System…Needs To Be Redesigned'

Will significantly shorten digital transformation development period

MIELY

Reported Earlier, Mitsubishi Electric Develops First-Ever System To Digitize Operator Expertise For Smarter Operations

TRGP

Reported Earlier, Targa Resources Prices $2B In Senior Notes: $1B 5.550% Due 2035 And $1B 6.125% Due 2055

Reported Earlier, Accenture Unveils AI Solutions To Help Businesses Leverage Google Cloud And Salesforce Technology

OXBR

Reported Earlier, Oxbridge Announces $3M Capital Raise Through Registered Offering And Private Placement

Unity also granted the initial purchasers of the Notes an option to purchase, within a 13-day period beginning on, and including, the date on which the Notes are first issued, up to an additional $90.0 million aggregate principal amount of Notes. The sale of the Notes to the initial purchasers is expected to close on February 27, 2025, subject to customary closing conditions.
The Notes will be general unsecured obligations of Unity and will not bear regular interest, and the principal amount of the Notes will not accrete. The Notes will mature on March 15, 2030, unless earlier converted, redeemed or repurchased.

Reported Earlier, Unity Prices Upsized $600M 0% Convertible Senior Notes Due 2030

Press Releases

PepGen Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4) to Newly Appointed Senior Vice President, Clinical Development

PepGen Announces Clinical Hold in the U.S. on IND Application to Initiate CONNECT2-EDO51 Phase 2 Study of PGN-EDO51 for Duchenne Muscular Dystrophy

SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of PepGen Inc. - PEPG

PepGen Announces CONNECT Program Updates

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of PepGen Inc. - PEPG

PepGen Announces Positive Initial Results, Including Robust Splicing Correction, from Ongoing FREEDOM-DM1 Trial in Patients with DM1

PepGen Reports Fourth Quarter and Year-End 2024 Financial Results and Recent Corporate Highlights

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