Benzinga's Top #PreMarket Losers

Avalanche Biotechnologies Inc AAVL shares declined 45.47 percent to $21.20 in pre-market trading following mixed AVA-101 data and various analyst downgrades. DBV Technologies SA - ADR DBVT shares dropped 3.13 percent to $26.32 in pre-market after falling 0.11 percent on Monday Transocean LTD RIG fell 1.53 percent to $17.34 in pre-market trading after dropping 0.90 percent on Monday. Twitter Inc TWTR shares fell 1.04 percent to $34.30 in pre-market trading. MKM Partners downgraded Twitter from Buy to Neutral and lowered the price target from $57.00 to $39.00. Randgold Resources Ltd. (ADR) GOLD shares tumbled 0.99 percent to $70.80 in pre-market trading. Gold futures fell 0.30 percent to trade at $1,182.20 an ounce.